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Treatment for Yersinia pestis

Diagnosis. If your doctor suspects plague, he or she may look for the Yersinia pestis bacteria in samples taken from your: Buboes. If you have the swollen lymph nodes (buboes) typical of bubonic plague, your doctor may use a needle to take a fluid sample from them (aspiration) Diagnosis and Treatment. Yersiniosis usually is diagnosed by detecting the organism in the stool of an infected person. Many laboratories do not routinely test for Yersinia, so it is important to notify laboratory personnel when yersiniosis is suspected so that special tests can be done. The organism can also be recovered from other sites. Yersinia pestis infection in Vietnam. II. Quantitative blood cultures and detection of endotoxin in the cerebrospinal fluid of patients with meningitis. Journal of Infectious Diseases, 1976;133:493-499. 7. Byrne WR, Welkos SL, Pitt ML, Davis KJ et al. Antibiotic treatment of experimental pneumonic plague in mice. Antimicrobial Agents an

Plague is caused by Yersinia pestis and is not commonly encountered in clinics, although natural plague foci are widely distributed around the world.Y. pestis has been listed as a category A bioterrorism agent. A neglected diagnosis will cause severe consequences. Therefore, this minireview briefly introduces the current understanding on Y. pestis and then focuses on practical aspects of. This subsequently led to specific antibiotic prophylaxis and therapy for Y. pestis. The use of antibiotics such as tetracycline and streptomycin for the treatment of plague has been embraced by the World Health Organization Expert Committee on Plague as the 'gold standard' treatment Treatment of Plague is a life-threatening infection caused by the organism Yersinia pestis, the bacterium that caused the 14th-century Black Death plague pandemic, Plague-causing bacteria still exist in the environment today, although their effect has abated dramatically. The major threat of plague these days comes not through natural transmission, but through intentional transmission, perhaps. Yersinia Pestis and the Relieving Effects of Cannabinoids While cases of yersinia pestis require hospitalization and antibiotics, we do know that medical cannabis is capable of helping to relieve some of its symptoms, including pain, muscle aches, headache, and nausea. Further research into the antibacterial properties of cannabis is needed

It is caused by the bacterium, Yersinia pestis. Humans usually get plague after being bitten by a rodent flea that is carrying the plague bacterium or by handling an animal infected with plague. Plague is infamous for killing millions of people in Europe during the Middle Ages. Today, modern antibiotics are effective in treating plague With prompt treatment of appropriate antibiotics, over 90% of people will survive. Without proper treatment, the Y. pestis bacteria could spread through the bloodstream and a person could develop septicemic plague

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Yersinia enterocolitica (Yersiniosis) | Yersinia | CDC

Plague - Diagnosis and treatment - Mayo Clini

Without proper antibiotic treatment, infection by Yersinia pestis led to death within a few days. Today, plague is easily treated with antibiotics and the use of standard precautions to prevent acquiring infection. Without prompt treatment, plague can cause serious illness or death, with a case-fatality ratio of 30% to 100% if left untreated However, Yersin actually linked plague with Y. pestis. Formerly named Pasteurella pestis, the organism was renamed Yersinia pestis in 1944. Every year, thousands of cases of the plague are still reported to the World Health Organization, although with proper antibiotic treatment, the prognosis for victims is now much better Antibiotics, such as streptomycin and chloramphenicol, are highly effective for all plague presentations if begun early. If antibiotics are given within the first 24 hours after the symptoms of pneumonic plague develop, mortality is significantly reduced Plague is a life-threatening zoonotic disease caused by Yersinia pestis.Zoonotic foci exist on several continents; however, resource-poor areas in sub-Saharan Africa account for most human cases ().The pathogenesis of plague involves facultative intracellular infection of host macrophages, followed by fulminant extracellular growth and bacteremia () Early treatment of plague with antibiotics is essential as a delay of >24 hours from the onset of symptoms is associated with high mortality. Post-exposure antibiotic prophylaxis is indicated in people who have been in close contact (within 2 m) with people with plague. Yersiniosis requires supportive care

Diagnosis and Treatment Yersinia CD

  1. The organism that causes plague, Yersinia pestis, lives in small rodents found most commonly in rural and semirural areas of Africa, Asia and the United States. The organism is transmitted to humans who are bitten by fleas that have fed on infected rodents or by humans handling infected animals
  2. Moxifloxacin is a fluoroquinolone antibiotic that inhibits A subunits of DNA gyrase (topoisomerase type II) and topoisomerase IV, resulting in inhibition of bacterial DNA replication and transcription. It is indicated in adults for treatment and prophylaxis of pneumonic or septicemic plague caused by Yersinia pestis
  3. utes. It is susceptible to sulfadiazine.
  4. ations
  5. istration as appropriate treatment

Plague is caused by Yersinia pestis bacteria. It can be a life-threatening infection if not treated promptly. Plague has caused several major epidemics in Europe and Asia over the last 2,000 years. Plague has most famously been called the Black Death because it can cause skin sores that form black scabs Read how you can stop itching. Natrabalm 100% Natural Cream stops itching. Natrabalm 100% natural emollient cream. Relieve and soothe itchy skin at night When plague is suspected doctors are able to put patient on an antibiotic like stretomycrin or gentamycin. There are other antibiotics but these are the two most likely to be described. If left untreated bubonic plague bacteria can multiply in the blood stream quickly causing, septicemic plague or if it goes to the lungs, pneumonic lungs Treatment of Yersinia pestis Infections Treatment of a suspected case of plague with antibiotics should be started as early as possible, without waiting for laboratory confirmation. Immediate treatment with antibiotics has dramat-ically reduced mortality due to the disease 1. J Infect Dis. 2016 Sep 15;214(6):970-7. doi: 10.1093/infdis/jiw290. Epub 2016 Jul 11. Adjunctive Corticosteroid Treatment Against Yersinia pestis Improves Bacterial Clearance, Immunopathology, and Survival in the Mouse Model of Bubonic Plague

Plague: Recognition, Treatment, and Preventio

Treatment of plague: promising alternatives to antibiotic

INTRODUCTION. In the genus Yersinia, three species are important human pathogens: Yersinia pestis, Yersinia enterocolitica, and Yersinia pseudotuberculosis [].The yersinioses are zoonotic infections of domestic and wild animals; humans are considered incidental hosts that do not contribute to the natural disease cycle Streptomycin is considered to be one of the effective antibiotics for the treatment of plague. In order to investigate the streptomycin resistance of Y.pestis in China, we evaluated streptomycin susceptibility of 536 Y.pestis strains in China in vitro using the minimal inhibitory concentration (MIC) and screened streptomycin resistance-associated genes (strA and strB) by PCR method Yersinia (formerly Pasteurella) pestis is a short bacillus that often shows bipolar staining (especially with Giemsa stain) and may resemble a safety pin. Massive human epidemics (eg, the Black Death of the Middle Ages, an epidemic in Manchuria in 1911) have occurred PATHOGENESIS Yersinia pestis is primarily a rodent pathogen, with humans being an accidental host when bitten by an infected rat flea. The flea draws viable Y. pestis organisms into its intestinal tract. These organisms multiply in the flea and block the flea's proventriculus. Some Y. pestis in the flea are then regurgitated when the flea gets its next blood meal thus transferring the. by Global Biodefense Staff. May 25, 2015. 3D rendering of Yersinia pestis. Credit: Shutterstock. The U.S. Food and Drug Administration earlier this month approved Avelox (moxifloxacin) to treat patients with plague, a rare and potentially fatal bacterial infection. The agency approval for plague includes use of the drug for the treatment of.

If you felt this information uselful, kindly make a small donation to my paypal : carlu.johnsons@gmail.com Commercial ads : aptyou.in (Printed Apparel) Yersi.. Yersinia pseudotuberculosis causes belly (abdominal) pain similar to appendicitis. Yersinia pestis causes the disease known as the plague. A stool culture may be used to diagnose Y. enterocolitica and sometimes Y. pseudotuberculosis Kinetics of the neutrophil to lymphocyte ratio (NLR) in the blood of Yersinia pestis-infected mice during treatment and recovery. NLRs were measured in the circulation of infected and naive mice (n = 7-12) before antibody therapy (open diamonds) and on days 3 (open symbols) and 7 (closed symbols) after infection The plague is an infection caused by a bacteria Yersinia pestis which is found on fleas, that live on small animals. The bacteria can be passed to a new host in three ways. The first way is when an infected flea moves to a new host and bites it, therefore transmitting the bacterial infection Bubonic plague is one of three types of plague caused by the plague bacterium (Yersinia pestis). One to seven days after exposure to the bacteria, flu-like symptoms develop. These symptoms include fever, headaches, and vomiting, as well as swollen and painful lymph nodes occur in the area closest to where the bacteria entered the skin. Occasionally, the swollen lymph nodes, known as buboes.

Plague is caused by the bacteria Yersinia pestis. Rodents, such as rats, carry the disease. It is spread by their fleas. People can get plague when they are bitten by a flea that carries the plague bacteria from an infected rodent. In rare cases, people get the disease when handling an infected animal. Plague lung infection is called pneumonic. Yersinia pestis was the bacterium that caused the Black Death and later epidemics throughout the Later Middle Ages and Early Modern period. Advertisement And since the plague tormented Europe for nearly 5,000 years, the study suggests that these immunity genes may have been pre-selected in the population long ago but recently became selected.

Y. pestis harbours three virulence plasmids—pFra, encoding the antiphagocytic capsular protein fraction 1 and the murine toxin that enables bacteria to survive in the flea gut; pCD (calcium dependency for growth at 37°C), also called pYV for Yersinia virulence, encoding V antigen and Yersinia outer proteins, which disrupt phagocytosis and. Plague is a severe infection caused by the gram-negative bacteria Yersinia pestis and often involving the lymph nodes and/or lungs. The bacteria are spread mainly by the rat flea. Depending on the form, plague can cause fever, chills, swollen lymph nodes, headache, a rapid heartbeat, cough, difficulty breathing, vomiting, and diarrhea Yersinia pestis in Dogs. Plague is a bacterial disease caused by the parasitic genus Yersinia pestis.This condition occurs worldwide. In the United States, it is predominantly found in the southwest between the months of May and October Untreated cases of bubonic or septicemic plague can become pneumonic plague as infection spreads to the lungs. People can also become infected by inhaling respiratory droplets containing Yersinia pestis from other infected humans or animals. Symptoms, which can develop one to three days after infection, include fever, chills, and body aches and. Yan ZQ, Zhou L, Zhao YK, Wang J, Huang LH, Hu KX, Liu HH, Wang H, Guo ZB, Song YJ, et al. Rapid quantitative detection of Yersinia pestis by lateral-flow immunoassay and up-converting phosphor technology-based biosensor. Sensor Actuat B-Chem. 2006;119(2):656-63. CrossRef Google Schola

Yersinia pestis. Y. pestis is the cause of bubonic, septicemic, and pneumonic plague. Plague is a zoonotic infection with its reservoirs in rodents and other animals. Humans can be considered accidental victims when they are bitten by rodent fleas or handle animal tissues or, rarely, inhale airborne bacteria from coughing patients or from. Yersinia pestis bacteria (shown in yellow), the organism known to cause the plague, is imaged through a microscope surrounding a rat flea's digestive system. (Source) The first recorded plague pandemic occurred in 541 AD and was termed the Plague of Justinian.. Named after Emperor Justinian I, the epicenter of this pandemic was the. Yersinia pestis Colony Morphology . Grey-white translucent colonies in 24 h on Blood Agar (BA) and Chocolate Agar (CA) at ambient and 35/37ºC (growth faster at 28ºC).1-2 mm colonies in 48 h that may be opaque and yellow Fried egg or hammered copper appearance on BA in older cultures Classification. Yersinia pestis. a nonmotile, gram-negative, facultative intracellular bacillus. non-lactose fermenting, oxidase negative, and does not produce H 2 S. reservoirs are rats and prairie dogs. transmitted via fleas. causes the bubonic plague (most common) and pneumonic plague Yersinia pestis is a gram negative, rod-shaped, facultative anaerobic bacterium, known for causing the plague.Y. pestis was first discovered by a French-born Swiss bacteriologist named Alexander Yersin in 1894. Yersin stumbled upon this bacterium while in China studying a plague epidemic there. However, before then, Y. pestis has been wreaking havoc throughout human history

Treatment of Yersinia Pestis, Yersinia Pestis SDefinition

Yersinia pestis is a nonmotile, non- spore -forming, pleomorphic, Gram-negative, facultative anaerobic, bipolar-staining bacillus bacterium belonging to the family Enterobacteriaceae. It is also catalase positive and oxidase negative. The bacteria elaborate a lipopolysaccharide endotoxin, coagulase, and a fibrinolysin, which are the principal. Endoscopy is currently the gold standard for the diagnosis of inflammatory bowel disease (IBD). The presence of macroscopic lesions along with the microscopic detection of inflammatory infiltration in the terminal ileum often leads the gastroenterologist to the diagnosis of Crohn's disease (CD). However, some of these cases could be, in fact, an infection caused by <i>Yersinia</i> spp. Epidemiology in New Zealand. Prior to 2014, the vast majority of cases of yersiniosis in New Zealand were caused by Yersinia enterocolitica biotype 4 (commonly found in pigs in New Zealand). In 2014 Y. pseudotuberculosis isolates accounted for almost half of all notifications and Y. enterocolitica biotype 2 has become the most common biotype isolated in New Zealand

Product Name: R & F® Yersinia pestis Chromogenic Plating Medium Page 1 of 4 SDS: Revision Date: 6/30/15 Cat. Number: M-1000 Product type: Bacteriological Media Company Identification: R & F Products, Inc. Contact: Phone USA 2725 Curtiss Street Emergency Contact: 630-969-5300. In a new study, researchers tested three vaccines that were designed to protect people against infection from the bacteria that cause plague, known as Yersinia pestis.To create the vaccines, the. Plague is a disease caused by Yersinia pestis that affects rodents (e.g., squirrels, prairie dogs, or mice), other mammals (e.g., rabbits or hares), and humans. These bacteria are found in many areas of the world, including the western United States. There are three forms of plague: bubonic (lymph node infection), pneumonic (lung infection) and. Yersinia pestis - Gerneal Infection, Symptoms, Diagnosis, and Treatment Yersinia pestis, the culprit behind the infamous Black Death, spread by rat fleas, has cast a shadow over human civilization, taken the lives of countless peasants and nobles alike like a violent brute who murders invariably

Yersinia pestis Description, Causes and Risk Factors: Yersinia pestis is the causative agent of the systemic invasive infectious disease often referred to as the Black Death. The Y. pestis is an extremely virulent pathogen that is likely to cause severe illness and death upon infection unless antibiotics are administered. In the past, Y. pestis has [ Yersinia pestis is the causative agent of plague, a devastating disease that in three pandemics resulted in more human deaths than any other infectious agent has (45, 69).Depending on the mode of transmission (flea bite or aerosol droplets), Y. pestis can precipitate bubonic or pneumonic plague infections (35, 53).High mortality and epidemic spread of plague, together with the possibility of. Russian and American use of Yersinia pestis as a Biological Weapon. In the city of Kirov, we maintained a quota of twenty tons of plague in our arsenals every year.. Kanatjan Alibekov, 1992. It is apparent that there has been a kind of ignoring of potentials for harm, Orrin G. Hatch of Utah, chairman of Senate Judiciary Committee. Plague is an acute (rapid onset and short course) contagious illness caused by bacteria called Yersinia pestis. These bacteria primarily infect rodents and their fleas; humans are incidentally infected by bites from infected fleas. In recent years, rodent and flea control has reduced the incidence of plague, and prompt treatment with. Yersinia pestis is a highly virulent bacterium which causes plague with a high mortality rate. The ability of Yersinia spp. to resist pathogenetic killing is the hallmark of pathogenesis of plague. Y. pestis causes natural disease of rats and other rodents. The infected host dies

Yersinia Pestis Bacteria and Medical Cannabis Treatmen

Yersinia pestis is the causative agent of the infamous bubonic plague, primary septicaemic plague, and primary pneumonic plague. Y. pestis was first discovered by Shibasaburo Kitasato and Alexandre Yersin, but due to Yersin's description of the bacteria being more accurate, this bacterium was named after him (3) For those suffering from plague, treatment is broad but the three main antibiotics are Streptomyacin, Tetracycline, and Chloramphenicol. The latter is the most frequently used. In 1995 the first multiresistant strain of Yersinia pestis was isolated in Madagascar. Most recently in 2000 and 2001, drug resistant strains of bubonic plague were.

Plague CD

Yersinia pestis disease : pathogenesis and treatment / Luther Lindler. Author: Lindler, Luther E. National Library of Medicine (U.S.) Publisher: Abstract: (CIT): Dr. Lindler is Director of Public Health Laboratory Services at the Department of Defense Global Emerging Infections Surveillance and Response System Treatment of Yersinia Pestis Without treatment the fatality rate is high - more than 90%. With treatment this drops to between 5 and 20%. Rapid treatment with antibiotics such as streptomycin and tetracycline is the most common procedure. [brighthub.com] Prognosis

Treatment of Yersinia Pestis Without treatment the fatality rate is high - more than 90%. With treatment this drops to between 5 and 20%. Rapid treatment with antibiotics such as streptomycin and tetracycline is the most common procedure Yersinia pestis used in an aerosol attack could cause cases of the pneumonic form of plague Yersinia pestis - Gerneal Infection, Symptoms, Diagnosis, and Treatment Yersinia pestis, the culprit behind the infamous Black Death, spread by rat fleas, has cast a shadow over human civilization, taken the lives of countless peasants and nobles alike like a violent brute who murders invariably Yersinia pestis expresses an envelope. Yersinia pestis. CHARACTERISTICS: Gram negative rod-ovoid 0.5-0.8 µm in width and 1-3 µm in length, bipolar staining (safety pin appearance), facultative intracellular, non-motile. PATHOGENICITY: Zoonotic disease; bubonic plague with lymphadenitis in nodes receiving drainage from site of flea bite, occuring in lymph nodes and inguinal areas.

Mongolia warns of suspected bubonic plague

Plague (Yersinia Pestis) Guide: Causes, Symptoms and

Yersinia bercovieri. Yersinia mollaretii. Yersinia rohdei. All are Gram-negative coccobacilli, and are members of the family Enterobacteriaceae. What is the best treatment? These species are generally associated with mild diarrhea, particularly in children. In such cases, the primary focus of therapy should be on appropriate rehydration Overview of Plague. Plague, caused by Yersinia pestis, is an acute and sometimes fatal bacterial zoonosis transmitted primarily by the fleas of rats and other rodents. Enzootic foci of sylvatic plague exist in the western USA and throughout the world, including Eurasia, Africa, and North and South America The etiologic agent of plague, Yersinia pestis, is a gram-negative coccobacillus and a facultative intracellular pathogen.Y. pestis exhibited the highest overall mortality rate of any infectious disease from its earliest recorded emergence through 1941 ().During 2010-2015, a mean of 650 cases were reported globally each year, with a case fatality rate of 23%-41% (depending on manifestation.

Transmission | Plague | CDC

Fleas become infected by feeding on rodents, such as the chipmunks, prairie dogs, ground squirrels, mice, and other mammals that are infected with the bacteria Yersinia pestis. Fleas transmit the plague bacteria to humans and other mammals during the feeding process. The plague bacteria are maintained in the blood systems of rodents Yersinia pestis Agent Information Sheet. Print. On this page: Agent, Y. pestis causes a zoonotic disease of rodents and in humans can take the form of bubonic, septicemic or pneumonic plague. Pathogenicity. Without treatment septicemic plague is 100% fatal. With treatment there is a 30 to 50% survival rate Yersinia pestis, the bacterium that causes bubonic plague, can survive within the ubiquitous soil protozoan, the amoeba, by producing proteins that protect against the latter microbe's digestion Yersinia pestis is an obligate parasite, meaning that it cannot reproduce without a host. Rodents are the primary hosts of the bacteria, which is spread through fleas. When a flea feeds on an. Heine HS, Louie A, Sorgel F, et al. Comparison of 2 antibiotics that inhibit protein synthesis for the treatment of infection with Yersinia pestis delivered by aerosol in a mouse model of pneumonic plague. J Infect Dis 2007 Sep 1;196(5):782-7 . HHS. Possession, use, and transfer of select agents and toxins: final rule. 42 CFR parts 73..

Bubonic plague symptoms treatment history | What isYersinia enterocolitica

Bubonic Plague: Symptoms, Causes, Treatment, Preventio

Introduction. Yersinia pestis, the causative agent of plague, usually harbours three plasmids (pPCP1, pMT1 and pCD1) that are necessary for the complete virulence of the pathogen; two of them, pPCP1 and pMT1, are species-specific while pCD1 is conserved among three human pathogenic yersiniae: Y. pestis, Yersinia pseudotuberculosis and Yersinia enterocolitica Abstract: Pneumonic plague is a lethal infectious disease caused by Yersinia pestis, a Tier-1 biothreat agent. Antibiotic treatment can save infected patients; however, therapy should begin within 24 h of symptom onset. As some Y. pestis strains showed an antibiotic resistance phenotype, an antibiotic susceptibility test (AST) must be performed Yersinia (Y.) pestis evolved from Y. pseudotuberculosis in Central Asia about 1,500-20,000 years ago [1,2]. Since then the agent has spread throughout the world in multiple waves [3]. Y. pestis is held responsible for three dreaded pandemics during the history of mankind. First records describe a pandemic wave named after a Roman emperor. The causative agent behind the plague is a bacterium by the name of Yersinia pestis. It was first isolated in 1894 by Alexandre Yersin, who proudly named one of the deadliest pathogens after himself (a bit of a dubious honor). Since then, these bacteria have been found on all continents except Antarctica [1,2]

The human Y. pestis infection is known to take on three main forms: pneumonic, septicemic and bubonic plagues. Belonging to the Enterobactericeae family, Yersinia pestis is a gram- negative rod-shaped bacterium. It is a facultative anaerobe that produces and consumes hydrogen for gas. It is also covered by a slime envelope that is heat labile Pneumonic plague is a lethal infectious disease caused by Yersinia pestis, a Tier-1 biothreat agent. Antibiotic treatment can save infected patients; however, therapy should begin within 24 h of symptom onset. As some Y. pestis strains showed an antibiotic resistance phenotype, an antibiotic susceptibility test (AST) must be performed. Performing the Clinical and Laboratory Standards Institute. Introduction. Yersinia pestis is a Gram negative bacterium listed as a category A infective agent that causes bubonic, septicemic, and pneumonic plague. 1 The latter form is of special interest to biodefense, as it is highly lethal and transmitted through aerosol. 2 Fraction 1 (F1) is the dominant surface antigen of Y. pestis and an important determinant in the virulence of this microorganism Specializes in Oral and Maxillofacial Surgery. Symptoms are similar: Meningitis is an infection of the tissues surrounding the brain. Symptoms may include fever, headache, a stiff neck (an inability to touch the chin to the chest) and a rash. Generally bacterial meningitis is more serious than viral An example of such a bacterium is Yersinia pestis (Y. pestis), the causative agent of plague, which is classified by the Centers for Disease Control and Prevention (CDC), based on its rapid disease progression, severity, and person-to-person transmission (Inglesby et al., 2000), as a Tier 1 select agent 1

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Yersinia pestis, the agent of plague, is one of a limited number of organisms that are regarded as serious potential bioterrorism or biowarfare threats. 1Y. pestis is a zoonotic pathogen which currently causes naturally-acquired plague in a number of countries around the world. The reservoir is principally rodents of various species, and. A Yersinia effector and a Pseudomonas a virulence protein define a family of cysteine proteases functioning in bacterial pathogenesis. Cell. 109:575-88. Straley S.C. and W.S. Bowmer. 1986. Virulence genes regulated at the transcriptional level by Ca2+ in Yersinia pestis include structural genes for outer membrane proteins. Infect. Immun. 51:445-54 Yersinia pestis is a very pathogenic organism to both humans and animals and before antibiotics had a very high mortality rate. Bubonic plague also has military significance and is listed by the Centers for Disease Control and Prevention as a Category A bioterrorism agent. Yersinia pestis is a gram-negative bacterium that causes plague, a highly contagious and lethal disease and the cause of three disease pandemics throughout human history. It is a zoonotic disease and exists in natural cycles involving transmission between rodent hosts and flea vectors. Humans are usually infected through bites from rodent fleas that carry the disease Yersinia pestis causes three types of plague—bubonic, septicemic, and pneumonic. All three types can be deadly. Modern antibiotics are often an effective treatment, however. The treatment needs to be started early in the infection, especially in the case of pneumonic plague. Some frequent signs and symptoms of plague are listed below

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